Executing the same process that I detailed in this entry, I upgraded support.ardee.com and same install hosted sites to DotNetNuke 4.5.0.
The upgrade went smooth, however, I got numerous timeout messages before the front page finally opened. I did not ever get the upgrade page. I see that the Control Panel is different, so that probably means that the installation did upgrade without any problems.
Great job DNN Core Team! Thank you for a great portal.